Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS).
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder displaying features reminiscent of premature senescence caused by skateboards germline mutations in the LMNA gene encoding lamin A and C, essential components of the nuclear lamina.By studying a family with homozygous LMNA mutation (K542N), we showed that HGPS can also be caused by m